Letrozole (2.5 mg)/ Femara for Fertility Treatment

Letrozole (2.5 mg)/ Femara Treatment to get pregnant naturally

Letrozole is widely used in IUI, IVF and Follicular study treatment. Many women conceived with this drug. India, Singapore and USA hospitals widely uses this drug for the treatment of fertility.

Women with anovulatory problem like PCOD patients can take this drug with help of medical prescription. The dosage varies according to the women’s height and conditions.

Two things this drug will do

1.   Ovulation induction

Ovulation Induction

It is chemically called aromatase Inhibitors. letrozole helps in uterine lining building and a lower miscarriage rate. It helps in egg formation and maturation. It also helps to release the ovum/egg naturally. This is known as ovulation induction.

2.   Super ovulation

It helps in developing the egg healthy and naturally in women’s uterus. Thus helps in ovulating the egg naturally who are also ovulating naturally. There are many chances of getting twins with this treatment. It creates 2-6 follicles per cycle per ovary. Women can be monitored with the help of ultrasound in ovulation days to

 Check for follicle rupture.

Treatment Procedure:

·        Day2/Day 3 – Ultrasound scan – to review the uterus, ovaries and scan for follicles.

·        Start taking Letrozole 2.5 mg on days 5,6,7,8, and 9.

·        Couples can start Intercourse from day 10 (days10, 12, 13, 14, 16)

·        Meanwhile check for the follicular rupture through ultrasound scan review from 10 th day- 15^th day.

·        If you want to check at home you can check with ovulation strip

·        You will find double line in ovulation strip on (day10-15).

·        Check home pregnancy test on Day 30-  Day 35

Side Effects

·        Hot flashes

·        Headaches

·        Breast tenderness

Questions from the Patients

Does letrozole make you dizzy?

Yes. Some women come with complaints of slight dizziness due to its effect. But it is tolerable and mild.

How long does letrozole stay in your system?

Letrozole is a medication that is metabolized rapidly in the body. It is not thought to have significant levels in the blood or tissues.

What are the long term side effects of letrozole?

It has no long term side effects

Can you drink on letrozole?

Drinks should be avoided If you are trying for baby through fertility treatment.

Can letrozole cause twins?

It helps more follicles to matures per cycle. So It may cause two or more eggs to ovulate thereby increases the chances of twins

How long does it take to ovulate after taking letrozole?

It helps to ovulate from day12- day16

Is letrozole better than Clomid?

Yes. Clomid prevents the thickening of uterus lining for egg implantation. But letrozole helps in thickening of endometrium.

How long can you take letrozole for infertility?

 You can try for 6 trials for natural pregnancy and then the doctors prescribe letrozole with Hcg trigger shots for IUI. They also prescribe fertility drugs as supportive medicines for the treatment.

6 questions from PCOS patient and here the answers

6 Questions From PCOS Patient And Solutions For The Questions

Most women about 80-90% feel panic when they are diagnose with PCOD/PCOS condition. Many questions arise from each lady’s mind and they like to Google for the answers until they satisfy with the solutions given in many websites or blogs. Here are the top 6 questions from PCOS patients discussed below.

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1.       How the small cysts remove from the ovaries?

2.       Why the small cysts to be remove from ovaries?

3.       What are the preventive measures to overcome the formation of new cyst?

4.       What are the home remedies to conceive naturally?

5.       Any other treatments other than medicines or surgery?

6.       How to get conceive?

These are the six questions play a major role in women’s life who is longing for a baby after many years of marriage. Check out the answers for the above questions. Here they are:

1.       How the small cysts remove from the ovaries?

The entire small cyst can be removed by laparoscopic method.  When a woman tries to conceive in many possible ways like natural, IUI, follicular study if they attend failure laparoscopic method will prefer for them.  Most of the fertility centers like Chennai fertility center, GG hospital, Ishwarya, Prashanth  prefer to go for laparoscopic method to clean ovaries from cysts. If you prefer to go for fertility center you should be strong enough to get words from doctors that you’re all immature follicles has to be removed by D.Lap method. No medicines will be given to remove all cysts from your ovaries.

2.       Why the small cysts to be remove from ovaries?

Cyst can disrupt the hormonal balance in PCOS woman which lead to difficulty in estimating time of ovulation. Not only that it makes our body to think that ovulation not occur so the lining of uterus will not grow for implantation. Ultimately it affects overall regulatory system in uterus and makes fertility ill.

For (e.g.) In PCOS patients progesterone level will be very low. Progesterone is produced by corpus luteum after ovulation occurs. This progesterone helps in thickening of uterus for embryo implantation. If ovulation not occurs ultimately the endometrial thickness will not grow for embryo.

These cysts which make increase LH secretion 3 times higher than FSH which disrupt in ovulation (rupture of egg). LH surge is main villain in women’s body who aim for getting pregnant.

In short, for hormonal disruption, to make ovaries clean from small cysts, to make female fertile, the doctors will suggest Diagnostic Laparoscopic Method (LEOS).

PILLS:

Birth control pills will be given to decrease the level of LH hormone and to prevent upcoming small cysts.

3. What are the preventive measures to overcome the formation of new cyst?

Birth control pills can be prescribed to prevent new cyst forming.

4. What are the home remedies to conceive naturally?

Many home remedies, acupuncture will help some extent in my knowledge.

1.    Soy Beans

 Soya bean is easily available in all super markets which have rich in phytoestrogen. Boiled soybean (1 cup) has to be taken in alternate days till your baby test is positive. It helps to balance your hormones, build your endometrial and helps your fertilized egg to implant in uterus. For patients who have implantation failure they go for embryo glue technique in IVF treatment. Naturally this soya bean has enzyme which makes the egg to implant in your uterus.

      2.  Vitamin D capsules

PCO patients lack in vitamin D can take cod liver oil capsules once in each day as a supplement. This helps in preventing the cyst formation further.

 3.    Daily Greens

Any spinach for about 4 teaspoon has to be included in diet. It is rich in folic acid which increases the quality of egg for conception. I would recommend spinach diet to all women trying to get pregnant till pregnancy test positive

 .4.    Apple Cider Vinegar, Cinnamon and Honey (10 ml) It helps in reducing weight along with exercise. This will prevent any cyst formation in uterus. It has to consume early in the morning.

 5.    Maca Root I have ordered through amazon. It is little bit costly but gave good results in balancing the hormones. It also boost fertility when consumed thrice in a week.

 6.    Evening PrimRose Oil One of my friend personally tried and got pregnant with this home remedy. Massaging on your lower abdomen increases the blood circulation in uterus. There is no rule to massage just apply and give warm hot compression.

 7.    Royal Jelly I have read many articles, news feed, reviews and blogs about royal jelly. It is taken from the saliva of queen bee. Easily available in online market. It is costly. It increases ER lining and boost your fertility 

 8.    Pomegranate I took one in each day without break to maintain my uterus healthy. 

 9.    Castor oil packs Applying castor oil on lower abdomen and give hot water compression to remove and cyst formation. It helps blood circulation in uterus. 

 10.  Reducing sugar intake and reducing gluten rich foods helps in conception without getting delay in cycles. 

5. Any other treatments other than medicines or surgery?

Yes, it’s all your choices to choose which way you want to go to reach the goal (baby). I chose Ayurvedic treatment first. I was not much comfortable and maintain my patience so I switched to allopathy. But when I went for allopathy medicines I chose acupuncture as a supportive method for a allopathy.

Acupuncture with small needles, the practitioners give support to the medical treatment. After laparoscopy 6 months later my doctor informed that I got new small cyst in right ovary. I just informed to acupuncturist. With the acupuncture treatment I went to next scan review. Even my doctor surprised to notice that cyst was removed. Acupuncturist said that the cyst will remove and it will go through menstrual period. Till now I wonder about this incident.

6. How to get conceive?

·        Trust in doctor’s treatment.

·        Stop googling for each and every symptom you have.

·        Take supportive treatments along with allopathy.

·        Track ovulation date by calendar or by ovulation kit.

·        Some people believe in mucus secretion but I almost confused with it. So my advice not to follow.

·        Be positive and be patient.

·        Moderate exercise and fertility diet.

·        Both pregnancy and menstrual symptoms are same.

·        Do not confuse if you even get abdominal pain or mucus white discharge.

Picture Quotes To get motivate during fertility treatment

Here are the below picture quotes to boost you when your confidence level goes down during fertility treatment. Cheer up! You will have a wonderful blast day soon.

Parenting begins the moment you may any conscious effort to care for your own health in preparation for enhancing your child's conception.

I am learning to trust the journey even when I do not understand it.

A strong woman looks a challenge dead in the eye and gives it a wink.

You are the sky. Everything else is a just the weather.

God's timing is perfect

Just keep swimming.

Hope is the only thing stronger than fear.

People ask,'So when are you going to have a baby?"

 If they only knew how hard we're trying

Patience is not the ability to keep a good attitude while waiting

You may have to fight a battle more than once to win it.

You don't have to see the whole staircase, just take the first step.

She who is brave is free.

Even miracles take a little time.

Inspirational quotes for fertility

1. We Still Hope                    
2. With a baby or without, you are valuable. You are whole. And you matter.                          
3. Don’t expect everyone to understand your journey, especially if they’ve never had to walk your path..
4. Even Miracles take a little time.                
5. Forget all the reasons it won’t work and believe the one reason it will.                  
6. Good things are going to happen                             
7. Infertility is HOPE                            
8. Just keep trying, it’s all you can do.                         
9. People cry, not because they’re weak, It’s because they’ve been strong for too long.                   
10. The moment you’re ready to quit is usually the moment right before the miracle happens.
11. Don’t Give Up.                 
12. Don’t Give Up.                 
13. The struggle is part of the story.                               
14. Sun will rise and we will try again                             
15. I will get pregnant (I just don't know when)                        
16. Trust the timing of your life                        
17. My body knows to conceive a healthy baby                        
18. My courage is stronger than my fear                      
19. Your body is adjusting and learning how to do it. Be patient.

G-CSF Injection / Filgrastim injection for fertility treatment

GCSF Injection/Filgrastim injection

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Brand name- Neupogen, Granix

What is G-CSF injection?

When your gynecologist found that the endometrial thickness is less than 7mm, then G-CSF injection will prescribed. This injection will help to thicken the endometrium. Sometimes the use of clomid will bring the ER thickness less than the 7mm ultimately decreases the fertility chance in women. With 24-36 hours, we can see thickness of endometrium doubled. It increases WBC cells, Immune cells that lines inside the uterus.

How is GCSF Injection/Filgrastim injection Administered?

G-CSF injection is given intra uterine. Patients are taken to theater or labour ward or IVF theater for this procedure.

Cost of Injection:

The cost of this procedure is 1000 INR. Cost of injection is 1500-3000 INR.

Pain :

The patients will not experience pain during the procedure. It is a outpatient procedure. Patients will experience slight discomfort during the procedure due to clamp insertion inside the vagina for injection. It is similar to IUI procedure.

How much thickness expected:

Within 24 hours we could see massive improvement in endometrial thickness. (from 0.1mm to 7-8mm increase level)

When to see doctor for fertility treatment

Know about yourself

To Know about yourself or In medical terms the fertility clinic will provide you Female counterpart form to fill up the details to give solution regarding your fertility issues. If you have any abnormalities below check list kindly visit doctor's office for the fertility treatment.

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Just Tick the coloum if you have the above symptoms

For example: For pcod patients, the mensus problem related to

•             Irregular periods
•             Moderate flow/ Scanty Flow
•             Abdominal/ Low back pain

Almost most of the pcod women will get periods from 35-70 days or even more than that. Some women will get periods only after taking pills.

Hormone Analysis

Coming to hormone analysis, Unless we go to lab we would not come to know how much we have these hormones in body which play major role in menstrual cycle.

For PCOD women, the LH hormone which should be <8 will always higher in Day2 of periods which means the high grade treatment like IUI, IVF tough hob to proceed.

Irregular periods:

Though irregular periods related to many factors and conditions. After marriage, this can create main stress to each women who willing to get pregnant naturally. The egg  release date (12-14 day of mensus) be a mysterious one to identify. Some women will use ovulation kit which makes them to identify ovulation period easily to some extent.

Reasons for Irregular periods

• Pregnancy
• PCOS due to immature ovarian cyst
• Hormonal disturbances
• Extreme diet/ Extreme exercise
• Thyroid problem which affects body metabolism
• Birth Control Pill
• Teenage- due to stress or initial puberty stages.

Heavy flow/Scanty Flow

• When there is clot in uterine layer
• Cyst present in uterus/ ovaries
• PCOD condition
• Uterine cancer
• Uterine infection
• Fluctuation in weight, high level of stress, restricted diet
• Fallopian tube block causes heavy bleeding

Extreme Abdominal pain

• Fallopian tube blockage
• PCOD
• Endometriosis
• Pelvic inflammatory diseases

Blood Analysis

Hormone LH which is high in blood level in PCOS patients.

PCOS women have reduced level of hormone progesterone.

High level of Prolactin Hormone level leads to low quality of egg production.

Scan Report

The scan review shows the image of ovaries, uterus and Fallopian tube. It gives the clear picture where the cyst present in female reproductive organ, structure of Fallopian tubes, ovaries, It also measures the size of ovaries and uterus. It shows the abnormalities like endometriosis, PCOD (many small cyst in ovaries), Ovarian cancer, clots and any variation in shapes of uterus,ovaries and Fallopian tubes.

PCOD/PCOS patients

PCO women has more than 10 follicles in ovary. Even I got 15-20 follicles in each ovary (Right and left) which arranged along peripheral of the ovary like pearls.

The size of the ovaries will be big because it holds many follicles. The size is bigger when compare to normal ovaries.

The uterus size is less when compare to normal healthy uterus. Healthy uterus always 6x3 in size. In short PCO women have big ovaries and small uterus as many immature follicles in the Right/left/both ovaries.